Progress in Gene Therapy of Hereditary Neurological Ion Channel Disease / 中国综合临床

Current therapies for hereditary neuropathy are often difficult to control or have low patient tolerance,so it is imperative to explore new therapies??Gene therapy has been shown that in many studies it may be applied to nervous system diseases and may become an effective treatment for hereditary nervous system ion channel diseases in the future??At the same time,the continuous progress of photogenetics, chemical genetics and gene editing technology also provides a good basis for the development of gene therapy for hereditary neuropathy??We will review the methods, mechanisms, transduction vectors, promoters and administration routes of gene therapy for hereditary neurological ion channel disease??

Epigenetic progress in obstructive sleep apnea syndrome / 中国综合临床

Obstructive sleep apnea syndrome is a kind of common sleep and respiratory disorder with unknown cause. Epigenetics is a branch of genetics that studies the genetic variation of gene expression under the condition of unchanged nucleotide sequence, including DNA methylation, histone modification, chromatin remodeling,and non coding RNA regulation.